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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF4
All Species:
22.12
Human Site:
S106
Identified Species:
32.44
UniProt:
O43172
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43172
NP_004688.2
522
58449
S106
I
N
V
S
T
D
D
S
E
V
K
A
C
L
R
Chimpanzee
Pan troglodytes
XP_520198
559
62217
S143
I
N
V
S
T
D
D
S
E
V
K
A
C
L
R
Rhesus Macaque
Macaca mulatta
XP_001102859
521
58408
S105
I
N
V
S
T
D
D
S
E
V
K
A
C
L
R
Dog
Lupus familis
XP_532038
521
58332
S105
I
N
V
S
T
D
D
S
E
V
K
A
C
L
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9DAW6
521
58352
S105
I
N
V
S
T
D
D
S
E
V
K
A
C
L
R
Rat
Rattus norvegicus
Q5BK30
415
45841
P12
S
L
L
L
R
Y
Y
P
P
G
I
M
L
E
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518220
390
43930
Chicken
Gallus gallus
Q5ZMA2
505
55116
Q94
L
H
S
F
T
L
R
Q
Q
L
Q
T
T
R
Q
Frog
Xenopus laevis
Q5FWQ6
415
45899
P12
R
F
L
L
R
Y
F
P
P
G
I
I
L
E
Y
Zebra Danio
Brachydanio rerio
Q1LV15
415
45916
P12
R
M
H
I
R
Y
Y
P
P
G
I
F
L
D
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7KNS3
411
46441
Honey Bee
Apis mellifera
XP_393186
525
59172
S98
I
N
V
S
T
D
D
S
E
V
K
R
N
L
R
Nematode Worm
Caenorhab. elegans
Q10051
492
53189
N89
E
W
D
T
V
M
L
N
S
F
S
L
R
Q
Q
Sea Urchin
Strong. purpuratus
XP_795434
502
56264
E94
A
Q
L
R
K
Y
G
E
P
I
C
L
F
S
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O22212
554
61823
K124
M
A
V
P
T
N
D
K
A
V
R
D
R
L
R
Baker's Yeast
Sacchar. cerevisiae
P20053
465
52424
P61
L
L
S
I
L
K
K
P
E
V
V
E
N
E
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.8
99
99.2
N.A.
98.8
25.4
N.A.
71.2
21
24.1
24.3
N.A.
22.2
58.2
22
62
Protein Similarity:
100
93.1
99.2
99.6
N.A.
99.4
40.6
N.A.
73.3
41.3
41.3
41.5
N.A.
39.6
72.9
40.6
77
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
0
6.6
0
0
N.A.
0
86.6
0
0
P-Site Similarity:
100
100
100
100
N.A.
100
6.6
N.A.
0
46.6
6.6
0
N.A.
0
86.6
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
40
31.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.7
51.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
0
0
0
0
0
7
0
0
32
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
7
0
32
0
0
% C
% Asp:
0
0
7
0
0
38
44
0
0
0
0
7
0
7
7
% D
% Glu:
7
0
0
0
0
0
0
7
44
0
0
7
0
19
7
% E
% Phe:
0
7
0
7
0
0
7
0
0
7
0
7
7
0
0
% F
% Gly:
0
0
0
0
0
0
7
0
0
19
0
0
0
0
0
% G
% His:
0
7
7
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
38
0
0
13
0
0
0
0
0
7
19
7
0
0
0
% I
% Lys:
0
0
0
0
7
7
7
7
0
0
38
0
0
0
0
% K
% Leu:
13
13
19
13
7
7
7
0
0
7
0
13
19
44
0
% L
% Met:
7
7
0
0
0
7
0
0
0
0
0
7
0
0
0
% M
% Asn:
0
38
0
0
0
7
0
7
0
0
0
0
13
0
0
% N
% Pro:
0
0
0
7
0
0
0
25
25
0
0
0
0
0
0
% P
% Gln:
0
7
0
0
0
0
0
7
7
0
7
0
0
7
13
% Q
% Arg:
13
0
0
7
19
0
7
0
0
0
7
7
13
7
44
% R
% Ser:
7
0
13
38
0
0
0
38
7
0
7
0
0
7
0
% S
% Thr:
0
0
0
7
50
0
0
0
0
0
0
7
7
0
0
% T
% Val:
0
0
44
0
7
0
0
0
0
50
7
0
0
0
0
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
25
13
0
0
0
0
0
0
0
19
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _